Ontology highlight
ABSTRACT:
SUBMITTER: Zhong J
PROVIDER: S-EPMC1642175 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Journal of virology 20060906 22
The virological and cellular consequences of persistent hepatitis C virus (HCV) infection have been elusive due to the absence of the requisite experimental systems. Here, we report the establishment and the characteristics of persistent in vitro infection of human hepatoma-derived cells by a recently described HCV genotype 2a infectious molecular clone. Persistent in vitro infection was characterized by the selection of viral variants that displayed accelerated expansion kinetics, higher peak t ...[more]