Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy.

ABSTRACT: The worldwide increase in the prevalence of multi-antibiotic-resistant bacteria has threatened the physician's ability to provide appropriate therapy for infections. The relationship between antimicrobial drug concentration and infecting pathogen population reduction is of primary interest. Using data derived from mice infected with the bacterium Pseudomonas aeruginosa and treated with a fluoroquinolone antibiotic, a mathematical model was developed that described relationships between antimicrobial drug exposures and changes in drug-susceptible and -resistant bacterial subpopulations at an infection site. Dosing regimens and consequent drug exposures that amplify or suppress the emergence of resistant bacterial subpopulations were identified and prospectively validated. Resistant clones s

SUBMITTER: Jumbe N 

PROVIDER: S-EPMC164285 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature