Ontology highlight
ABSTRACT:
SUBMITTER: Joet T
PROVIDER: S-EPMC164611 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Joet Thierry T Eckstein-Ludwig Ursula U Morin Christophe C Krishna Sanjeev S
Proceedings of the National Academy of Sciences of the United States of America 20030605 13
Chemotherapy of malaria parasites is limited by established drug resistance and lack of novel targets. Intraerythrocytic stages of Plasmodium falciparum are wholly dependent on host glucose for energy. Glucose uptake is mediated by a parasite-encoded facilitative hexose transporter (PfHT). We report that O-3 hexose derivatives inhibit uptake of glucose and fructose by PfHT when expressed in Xenopus oocytes. Selectivity of these derivatives for PfHT is confirmed by lack of inhibition of hexose tr ...[more]