Ontology highlight
ABSTRACT:
SUBMITTER: Pevzner P
PROVIDER: S-EPMC164646 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Pevzner Pavel P Tesler Glenn G
Proceedings of the National Academy of Sciences of the United States of America 20030616 13
The human and mouse genomic sequences provide evidence for a larger number of rearrangements than previously thought and reveal extensive reuse of breakpoints from the same short fragile regions. Breakpoint clustering in regions implicated in cancer and infertility have been reported in previous studies; we report here on breakpoint clustering in chromosome evolution. This clustering reveals limitations of the widely accepted random breakage theory that has remained unchallenged since the mid-19 ...[more]