Ontology highlight
ABSTRACT:
SUBMITTER: Weber T
PROVIDER: S-EPMC164649 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Weber Thomas T Gopfert Martin C MC Winter Harald H Zimmermann Ulrike U Kohler Hanni H Meier Alexandra A Hendrich Oliver O Rohbock Karin K Robert Daniel D Knipper Marlies M
Proceedings of the National Academy of Sciences of the United States of America 20030602 13
Prestin, the fifth member of the anion transporter family SLC26, is the outer hair cell molecular motor thought to be responsible for active mechanical amplification in the mammalian cochlea. Active amplification is present in a variety of other auditory systems, yet the prevailing view is that prestin is a motor molecule unique to mammalian ears. Here we identify prestin-related SLC26 proteins that are expressed in the auditory organs of nonmammalian vertebrates and insects. Sequence comparison ...[more]