Ontology highlight
ABSTRACT:
SUBMITTER: Kim SW
PROVIDER: S-EPMC164762 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Kim Seung-Whan SW Park Keunhee K Kwak Eunyee E Choi Eunho E Lee Seunghee S Ham Jungyeob J Kang Heonjoong H Kim Jong Man JM Hwang Seung Yong SY Kong Young-Yun YY Lee Keesook K Lee Jae Woon JW
Molecular and cellular biology 20030501 10
Activating signal cointegrator 2 (ASC-2), a cancer-amplified transcriptional coactivator of nuclear receptors and many other transcription factors, contains two LXXLL-type nuclear receptor interaction domains. Interestingly, the second LXXLL motif is highly specific to the liver X receptors (LXRs). In cotransfection, DN2, an ASC-2 fragment encompassing this motif, exerts a potent dominant-negative effect on transactivation by LXRs, which is rescued by ectopic coexpression of the full-length ASC- ...[more]