Structural insight into the antibiotic action of telithromycin against resistant mutants.
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ABSTRACT: The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.
SUBMITTER: Berisio R
PROVIDER: S-EPMC164882 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
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