Structural insight into the antibiotic action of telithromycin against resistant mutants.
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ABSTRACT:
SUBMITTER: Berisio R
PROVIDER: S-EPMC164882 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Publications
Structural insight into the antibiotic action of telithromycin against resistant mutants.
Berisio Rita R Harms Joerg J Schluenzen Frank F Zarivach Raz R Hansen Harly A S HA Fucini Paola P Yonath Ada A
Journal of bacteriology 20030701 14
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains. ...[more]
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