Ontology highlight
ABSTRACT:
SUBMITTER: Delorme V
PROVIDER: S-EPMC165085 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Delorme Violaine V Cayla Xavier X Faure Grazyna G Garcia Alphonse A Tardieux Isabelle I
Molecular biology of the cell 20030206 5
Actin polymerization in Apicomplexa protozoa is central to parasite motility and host cell invasion. Toxofilin has been characterized as a protein that sequesters actin monomers and caps actin filaments in Toxoplasma gondii. Herein, we show that Toxofilin properties in vivo as in vitro depend on its phosphorylation. We identify a novel parasitic type 2C phosphatase that binds the Toxofilin/G-actin complex and a casein kinase II-like activity in the cytosol, both of which modulate the phosphoryla ...[more]