Length of Epstein-Barr virus termini as a determinant of epithelial cell clonal emergence.
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ABSTRACT:
SUBMITTER: Moody CA
PROVIDER: S-EPMC165260 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
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Length of Epstein-Barr virus termini as a determinant of epithelial cell clonal emergence.
Moody Cary A CA Scott Rona S RS Su Tao T Sixbey John W JW
Journal of virology 20030801 15
Reiterated terminal sequences of Epstein-Barr virus (EBV) DNA are numerically heterogeneous among infectious virions, providing a viral measure of clonality in infected cells. After in vitro infection, carcinoma cells bearing EBV episomes with fewer terminal repeats (TRs) proliferated faster. In single-cell clones, TR number varied inversely to the quantity of latent membrane protein 2A (LMP2A) transcripts whose unspliced precursors cross joined TRs. Thus, EBV clonality may reflect selection for ...[more]
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