Ontology highlight
ABSTRACT:
SUBMITTER: Brychzy A
PROVIDER: S-EPMC165632 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Brychzy Alexander A Rein Theo T Winklhofer Konstanze F KF Hartl F Ulrich FU Young Jason C JC Obermann Wolfgang M J WM
The EMBO journal 20030701 14
In the eukaryotic cytosol, Hsp70 and Hsp90 cooperate with various co-chaperone proteins in the folding of a growing set of substrates, including the glucocorticoid receptor (GR). Here, we analyse the function of the co-chaperone Tpr2, which contains two chaperone-binding TPR domains and a DnaJ homologous J domain. In vivo, an increase or decrease in Tpr2 expression reduces GR activation, suggesting that Tpr2 is required at a narrowly defined expression level. As shown in vitro, Tpr2 recognizes b ...[more]