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Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription.

ABSTRACT: The x-ray structure of complete RNA polymerase II from Saccharomyces cerevisiae has been determined, including a heterodimer of subunits Rpb4 and Rpb7 not present in previous "core" polymerase II structures. The heterodimer maintains the polymerase in the conformation of a transcribing complex, may bind RNA as it emerges from the enzyme, and is in a position to interact with general transcription factors and the Mediator of transcriptional regulation.

SUBMITTER: Bushnell DA

PROVIDER: S-EPMC165814 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature

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Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription.

Bushnell David A DA Kornberg Roger D RD

Proceedings of the National Academy of Sciences of the United States of America 20030513 12

The x-ray structure of complete RNA polymerase II from Saccharomyces cerevisiae has been determined, including a heterodimer of subunits Rpb4 and Rpb7 not present in previous "core" polymerase II structures. The heterodimer maintains the polymerase in the conformation of a transcribing complex, may bind RNA as it emerges from the enzyme, and is in a position to interact with general transcription factors and the Mediator of transcriptional regulation. ...[more]

PMID: 12746498

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