A transcription map of the 6p22.3 reading disability locus identifying candidate genes.
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ABSTRACT:
SUBMITTER: Londin ER
PROVIDER: S-EPMC166143 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Publications
A transcription map of the 6p22.3 reading disability locus identifying candidate genes.
Londin Eric R ER Meng Haiying H Gruen Jeffrey R JR
BMC genomics 20030630 1
<h4>Background</h4>Reading disability (RD) is a common syndrome with a large genetic component. Chromosome 6 has been identified in several linkage studies as playing a significant role. A more recent study identified a peak of transmission disequilibrium to marker JA04 (G72384) on chromosome 6p22.3, suggesting that a gene is located near this marker.<h4>Results</h4>In silico cloning was used to identify possible candidate genes located near the JA04 marker. The 2 million base pairs of sequence ...[more]
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