Ontology highlight
ABSTRACT:
SUBMITTER: Charalambous M
PROVIDER: S-EPMC166222 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Charalambous Marika M Smith Florentia M FM Bennett William R WR Crew Tracey E TE Mackenzie Francesca F Ward Andrew A
Proceedings of the National Academy of Sciences of the United States of America 20030626 14
To investigate the function of the Grb10 adapter protein, we have generated mice in which the Grb10 gene was disrupted by a gene-trap insertion. Our experiments confirm that Grb10 is subject to genomic imprinting with the majority of Grb10 expression arising from the maternally inherited allele. Consistent with this, disruption of the maternal allele results in overgrowth of both the embryo and placenta such that mutant mice are at birth approximately 30% larger than normal. This observation est ...[more]