Ontology highlight
ABSTRACT:
SUBMITTER: Cota D
PROVIDER: S-EPMC166293 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Cota Daniela D Marsicano Giovanni G Tschöp Matthias M Grübler Yvonne Y Flachskamm Cornelia C Schubert Mirjam M Auer Dorothee D Yassouridis Alexander A Thöne-Reineke Christa C Ortmann Sylvia S Tomassoni Federica F Cervino Cristina C Nisoli Enzo E Linthorst Astrid C E AC Pasquali Renato R Lutz Beat B Stalla Günter K GK Pagotto Uberto U
The Journal of clinical investigation 20030801 3
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness. As compared with WT (CB1+/+) littermates, mice lacking CB1 (CB1-/-) exhibited reduced spontaneous caloric intake and, as a consequence of reduced total fat mass, decreased body weight. In young CB1-/- mice, the lean phenotype is predominantly caused by decreased ca ...[more]