Ontology highlight
ABSTRACT:
SUBMITTER: Miyakawa T
PROVIDER: S-EPMC166425 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Miyakawa Tsuyoshi T Leiter Lorene M LM Gerber David J DJ Gainetdinov Raul R RR Sotnikova Tatyana D TD Zeng Hongkui H Caron Marc G MG Tonegawa Susumu S
Proceedings of the National Academy of Sciences of the United States of America 20030708 15
Calcineurin (CN), a calcium- and calmodulin-dependent protein phosphatase, plays a significant role in the central nervous system. Previously, we reported that forebrain-specific CN knockout mice (CN mutant mice) have impaired working memory. To further analyze the behavioral effects of CN deficiency, we subjected CN mutant mice to a comprehensive behavioral test battery. Mutant mice showed increased locomotor activity, decreased social interaction, and impairments in prepulse inhibition and lat ...[more]