Ontology highlight
ABSTRACT:
SUBMITTER: Berry C
PROVIDER: S-EPMC1664696 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Berry Charles C Hannenhalli Sridhar S Leipzig Jeremy J Bushman Frederic D FD
PLoS computational biology 20061101 11
DNA sequences from retroviruses, retrotransposons, DNA transposons, and parvoviruses can all become integrated into the human genome. Accumulation of such sequences accounts for at least 40% of our genome today. These integrating elements are also of interest as gene-delivery vectors for human gene therapy. Here we present a comprehensive bioinformatic analysis of integration targeting by HIV, MLV, ASLV, SFV, L1, SB, and AAV. We used a mathematical method which allowed annotation of each base pa ...[more]