Ontology highlight
ABSTRACT:
SUBMITTER: Pfeifer A
PROVIDER: S-EPMC1679709 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Pfeifer Alexander A Eigenbrod Sabina S Al-Khadra Saba S Hofmann Andreas A Mitteregger Gerda G Moser Markus M Bertsch Uwe U Kretzschmar Hans H
The Journal of clinical investigation 20061201 12
Prion diseases are fatal neurodegenerative diseases characterized by the accumulation of PrP(Sc), the infectious and protease-resistant form of the cellular prion protein (PrP(C)). We generated lentivectors expressing PrP(C)-specific short hairpin RNAs (shRNAs) that efficiently silenced expression of the prion protein gene (Prnp) in primary neuronal cells. Treatment of scrapie-infected neuronal cells with these lentivectors resulted in an efficient and stable suppression of PrP(Sc) accumulation. ...[more]