Ontology highlight
ABSTRACT:
SUBMITTER: Nakajima A
PROVIDER: S-EPMC1679768 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Nakajima Akihito A Komazawa-Sakon Sachiko S Takekawa Mutsuhiro M Sasazuki Tomonari T Yeh Wen-Chen WC Yagita Hideo H Okumura Ko K Nakano Hiroyasu H
The EMBO journal 20061116 23
Inhibition of NF-kappaB activation increases susceptibility to tumor necrosis factor (TNF)alpha-induced cell death, concurrent with caspases and prolonged c-Jun N-terminal kinase (JNK) activation, and reactive oxygen species (ROS) accumulation. However, the detailed mechanisms are unclear. Here we show that cellular FLICE-inhibitory protein (c-FLIP) is rapidly lost in NF-kappaB activation-deficient, but not wild-type fibroblasts upon TNFalpha stimulation, indicating that NF-kappaB normally maint ...[more]