A theoretical framework for specificity in cell signaling.
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ABSTRACT:
SUBMITTER: Komarova NL
PROVIDER: S-EPMC1681467 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
A theoretical framework for specificity in cell signaling.
Komarova Natalia L NL Zou Xiufen X Nie Qing Q Bardwell Lee L
Molecular systems biology 20051018
Different cellular signal transduction pathways are often interconnected, so that the potential for undesirable crosstalk between pathways exists. Nevertheless, signaling networks have evolved that maintain specificity from signal to cellular response. Here, we develop a framework for the analysis of networks containing two or more interconnected signaling pathways. We define two properties, specificity and fidelity, that all pathways in a network must possess in order to avoid paradoxical situa ...[more]
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