Ontology highlight
ABSTRACT:
SUBMITTER: Smith JJ
PROVIDER: S-EPMC1681483 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Smith Jennifer J JJ Sydorskyy Yaroslav Y Marelli Marcello M Hwang Daehee D Bolouri Hamid H Rachubinski Richard A RA Aitchison John D JD
Molecular systems biology 20060221
Cells respond to fatty acid exposure by metabolic reorganization and proliferation of peroxisomes. Described here is the development and application of a genome-wide screen to identify nonessential yeast genes necessary for efficient metabolism of myristic and oleic acids. Comparison of the resultant fitness data set with an integrated data set of genes transcriptionally responsive to fatty acids revealed very little overlap between the data sets. Furthermore, the fitness data set enriched for g ...[more]