When transcriptome meets metabolome: fast cellular responses of yeast to sudden relief of glucose limitation.
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ABSTRACT:
SUBMITTER: Kresnowati MT
PROVIDER: S-EPMC1681515 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Publications
When transcriptome meets metabolome: fast cellular responses of yeast to sudden relief of glucose limitation.
Kresnowati M T A P MT van Winden W A WA Almering M J H MJ ten Pierick A A Ras C C Knijnenburg T A TA Daran-Lapujade P P Pronk J T JT Heijnen J J JJ Daran J M JM
Molecular systems biology 20060912
Within the first 5 min after a sudden relief from glucose limitation, Saccharomyces cerevisiae exhibited fast changes of intracellular metabolite levels and a major transcriptional reprogramming. Integration of transcriptome and metabolome data revealed tight relationships between the changes at these two levels. Transcriptome as well as metabolite changes reflected a major investment in two processes: adaptation from fully respiratory to respiro-fermentative metabolism and preparation for growt ...[more]
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