Ontology highlight
ABSTRACT:
SUBMITTER: Cochella L
PROVIDER: S-EPMC1687177 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Cochella Luisa L Green Rachel R
Science (New York, N.Y.) 20050501 5725
During transfer RNA (tRNA) selection, a cognate codon:anticodon interaction triggers a series of events that ultimately results in the acceptance of that tRNA into the ribosome for peptide-bond formation. High-fidelity discrimination between the cognate tRNA and near- and noncognate ones depends both on their differential dissociation rates from the ribosome and on specific acceleration of forward rate constants by cognate species. Here we show that a mutant tRNA(Trp) carrying a single substitut ...[more]