Cluster-Buster: Finding dense clusters of motifs in DNA sequences.
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ABSTRACT:
SUBMITTER: Frith MC
PROVIDER: S-EPMC168947 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Publications
Cluster-Buster: Finding dense clusters of motifs in DNA sequences.
Frith Martin C MC Li Michael C MC Weng Zhiping Z
Nucleic acids research 20030701 13
The signals that determine activation and repression of specific genes in response to appropriate stimuli are one of the most important, but least understood, types of information encoded in genomic DNA. The nucleotide sequence patterns, or motifs, preferentially bound by various transcription factors have been collected in databases. However, these motifs appear to be individually too short and degenerate to enable detection of functional enhancer and silencer elements within a large genome. Se ...[more]
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