Ontology highlight
ABSTRACT:
SUBMITTER: Matsui M
PROVIDER: S-EPMC16907 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
Matsui M M Motomura D D Karasawa H H Fujikawa T T Jiang J J Komiya Y Y Takahashi S S Taketo M M MM
Proceedings of the National Academy of Sciences of the United States of America 20000801 17
Muscarinic acetylcholine receptors consist of five distinct subtypes and have been important targets for drug development. In the periphery, muscarinic acetylcholine receptors mediate cholinergic signals to autonomic organs, but specific physiological functions of each subtype remain poorly elucidated. Here, we have constructed and analyzed mutant mice lacking the M(3) receptor and have demonstrated that this subtype plays key roles in salivary secretion, pupillary constriction, and bladder detr ...[more]