Ontology highlight
ABSTRACT:
SUBMITTER: Hentschel HG
PROVIDER: S-EPMC1691788 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Hentschel H G E HG Glimm Tilmann T Glazier James A JA Newman Stuart A SA
Proceedings. Biological sciences 20040801 1549
We describe a 'reactor-diffusion' mechanism for precartilage condensation based on recent experiments on chondrogenesis in the early vertebrate limb and additional hypotheses. Cellular differentiation of mesenchymal cells into subtypes with different fibroblast growth factor (FGF) receptors occurs in the presence of spatio-temporal variations of FGFs and transforming growth factor-betas (TGF-betas). One class of differentiated cells produces elevated quantities of the extracellular matrix protei ...[more]