Ontology highlight
ABSTRACT:
SUBMITTER: Makabe K
PROVIDER: S-EPMC1693819 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Makabe Koki K McElheny Dan D Tereshko Valentia V Hilyard Aaron A Gawlak Grzegorz G Yan Shude S Koide Akiko A Koide Shohei S
Proceedings of the National Academy of Sciences of the United States of America 20061108 47
Although the beta-rich self-assemblies are a major structural class for polypeptides and the focus of intense research, little is known about their atomic structures and dynamics due to their insoluble and noncrystalline nature. We developed a protein engineering strategy that captures a self-assembly segment in a water-soluble molecule. A predefined number of self-assembling peptide units are linked, and the beta-sheet ends are capped to prevent aggregation, which yields a mono-dispersed solubl ...[more]