Ontology highlight
ABSTRACT:
SUBMITTER: Bowman JC
PROVIDER: S-EPMC1693977 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Bowman J C JC Abruzzo G K GK Flattery A M AM Gill C J CJ Hickey E J EJ Hsu M J MJ Kahn J Nielsen JN Liberator P A PA Misura A S AS Pelak B A BA Wang T C TC Douglas C M CM
Antimicrobial agents and chemotherapy 20061002 12
The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-beta-D-glucan synthase from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated infection, caspofungin prolonged survival and reduced the kidney fungal burden. Caspofungin was at least as effective as amphotericin B against these filamentous fungi in vivo. ...[more]