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Genetic environment of acquired bla(ACC-1) beta-lactamase gene in Enterobacteriaceae isolates.

ABSTRACT: We studied the genetic organization of bla(ACC-1) in 14 isolates of Enterobacteriaceae from France, Tunisia, and Germany. In a common ancestor, ISEcp1 was likely involved in the mobilization of this gene from the Hafnia alvei chromosome to a plasmid. Other genetic events involving insertion sequences (particularly IS26), transposons (particularly Tn1696), or sulI-type integrons have occurred, leading to complex genetic environments.

SUBMITTER: Doloy A

PROVIDER: S-EPMC1693989 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature

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Genetic environment of acquired bla(ACC-1) beta-lactamase gene in Enterobacteriaceae isolates.

Doloy A A Verdet C C Gautier V V Decré D D Ronco E E Hammami A A Philippon A A Arlet G G

Antimicrobial agents and chemotherapy 20060918 12

We studied the genetic organization of bla(ACC-1) in 14 isolates of Enterobacteriaceae from France, Tunisia, and Germany. In a common ancestor, ISEcp1 was likely involved in the mobilization of this gene from the Hafnia alvei chromosome to a plasmid. Other genetic events involving insertion sequences (particularly IS26), transposons (particularly Tn1696), or sulI-type integrons have occurred, leading to complex genetic environments. ...[more]

PMID: 16982793

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