Yersinia pseudotuberculosis adhesins regulate tissue-specific colonization and immune cell localization in a mouse model of systemic infection.
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ABSTRACT:
SUBMITTER: Hudson KJ
PROVIDER: S-EPMC1695483 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
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Yersinia pseudotuberculosis adhesins regulate tissue-specific colonization and immune cell localization in a mouse model of systemic infection.
Hudson Krischan J KJ Bouton Amy H AH
Infection and immunity 20060818 11
Yersinia pseudotuberculosis mutants deficient for the adhesins invasin and/or YadA were injected intravenously into BALB/c mice. Invasin expression inhibited colonization of the liver and spleen. YadA decreased liver colonization but promoted growth within the lung. The persistence of leukocytes within liver microabscesses correlated with enhanced colonization and lack of adhesin expression. ...[more]
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