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Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of Actinobacillus actinomycetemcomitans.

ABSTRACT: Clinical Actinobacillus actinomycetemcomitans produces cytolethal distending toxin (CDT) with titers ranging from 10(2) to 10(8) U/mg. Single nucleotide polymorphism analysis of the cdt gene in clinical isolates identified a variation of a single amino acid at residue 281 of CdtB, which significantly affected CDT toxicity by modulating the chromatin-degrading activity of CdtB.

SUBMITTER: Nishikubo S 

PROVIDER: S-EPMC1698065 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature

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Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of Actinobacillus actinomycetemcomitans.

Nishikubo Shuichi S   Ohara Masaru M   Ikura Masae M   Katayanagi Katsuo K   Fujiwara Tamaki T   Komatsuzawa Hitoshi H   Kurihara Hidemi H   Sugai Motoyuki M  

Infection and immunity 20060918 12

Clinical Actinobacillus actinomycetemcomitans produces cytolethal distending toxin (CDT) with titers ranging from 10(2) to 10(8) U/mg. Single nucleotide polymorphism analysis of the cdt gene in clinical isolates identified a variation of a single amino acid at residue 281 of CdtB, which significantly affected CDT toxicity by modulating the chromatin-degrading activity of CdtB. ...[more]

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