Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis.
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ABSTRACT:
SUBMITTER: Miethke M
PROVIDER: S-EPMC1698241 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
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Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis.
Miethke Marcus M Westers Helga H Blom Evert-Jan EJ Kuipers Oscar P OP Marahiel Mohamed A MA
Journal of bacteriology 20060929 24
Iron deprivation in bacteria causes the derepression of genes controlled by the ferric uptake regulator (Fur). The present microarray analysis of iron-starved Bacillus subtilis cells grown in minimal medium unveils additional physiological effects on a large number of genes linked to stringent-response regulation and to genes involved in amino acid biosynthesis associated with pathways essential for bacillibactin production. ...[more]
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