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Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis.

ABSTRACT: Iron deprivation in bacteria causes the derepression of genes controlled by the ferric uptake regulator (Fur). The present microarray analysis of iron-starved Bacillus subtilis cells grown in minimal medium unveils additional physiological effects on a large number of genes linked to stringent-response regulation and to genes involved in amino acid biosynthesis associated with pathways essential for bacillibactin production.

SUBMITTER: Miethke M 

PROVIDER: S-EPMC1698241 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature

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Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis.

Miethke Marcus M   Westers Helga H   Blom Evert-Jan EJ   Kuipers Oscar P OP   Marahiel Mohamed A MA  

Journal of bacteriology 20060929 24

Iron deprivation in bacteria causes the derepression of genes controlled by the ferric uptake regulator (Fur). The present microarray analysis of iron-starved Bacillus subtilis cells grown in minimal medium unveils additional physiological effects on a large number of genes linked to stringent-response regulation and to genes involved in amino acid biosynthesis associated with pathways essential for bacillibactin production. ...[more]