Ontology highlight
ABSTRACT:
SUBMITTER: Marienfeld RB
PROVIDER: S-EPMC1698548 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Marienfeld Ralf B RB Palkowitsch Lysann L Ghosh Sankar S
Molecular and cellular biology 20060925 24
Previous studies have demonstrated that peptides corresponding to a six-amino-acid NEMO-binding domain from the C terminus of IkappaB kinase alpha (IKKalpha) and IKKbeta can disrupt the IKK complex and block NF-kappaB activation. We have now mapped and characterized the corresponding amino-terminal IKK-binding domain (IBD) of NEMO. Peptides corresponding to the IBD were efficiently recruited to the IKK complex but displayed only a weak inhibitory potential on cytokine-induced NF-kappaB activity. ...[more]