Ontology highlight
ABSTRACT:
SUBMITTER: Huang W
PROVIDER: S-EPMC1698740 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Huang Wei W Dobberfuhl Adam A Filippopoulos Theodoros T Ingelsson Martin M Fileta John B JB Poulin Nathaniel R NR Grosskreutz Cynthia L CL
The American journal of pathology 20050901 3
In glaucoma, retinal ganglion cells (RGCs) die by apoptosis, generally attributed to an elevated intraocular pressure (IOP). We now describe the impact of elevated IOP in the rat on expression of caspase 8 and caspase 9, initiators of the extrinsic and intrinsic caspase cascades, respectively. Activation of both caspases was demonstrated by the presence of cleaved forms of the caspases and the detection of cleaved Bid and PARP, downstream consequences of caspase activation. Surprisingly, the abs ...[more]