Global methylation screening in the Arabidopsis thaliana and Mus musculus genome: applications of virtual image restriction landmark genomic scanning (Vi-RLGS).
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ABSTRACT:
SUBMITTER: Matsuyama T
PROVIDER: S-EPMC169878 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Publications
Global methylation screening in the Arabidopsis thaliana and Mus musculus genome: applications of virtual image restriction landmark genomic scanning (Vi-RLGS).
Matsuyama Tomoki T Kimura Makoto T MT Koike Kuniaki K Abe Tomoko T Nakano Takeshi T Asami Tadao T Ebisuzaki Toshikazu T Held William A WA Yoshida Shigeo S Nagase Hiroki H
Nucleic acids research 20030801 15
Understanding the role of 'epigenetic' changes such as DNA methylation and chromatin remodeling has now become critical in understanding many biological processes. In order to delineate the global methylation pattern in a given genomic DNA, computer software has been developed to create a virtual image of restriction landmark genomic scanning (Vi-RLGS). When using a methylation- sensitive enzyme such as NotI as the restriction landmark, the comparison between real and in silico RLGS profiles of ...[more]
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