Thrombin induces rapid PAR1-mediated non-classical FGF1 release.
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ABSTRACT:
SUBMITTER: Duarte M
PROVIDER: S-EPMC1698861 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Publications
Thrombin induces rapid PAR1-mediated non-classical FGF1 release.
Duarte Maria M Kolev Vihren V Soldi Raffaella R Kirov Alexander A Graziani Irene I Oliveira Silvia Marta SM Kacer Doreen D Friesel Robert R Maciag Thomas T Prudovsky Igor I
Biochemical and biophysical research communications 20060928 3
Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating that this effect was dependent on PAR1. Similarly to thrombin, FGF1 expression and release were induced by TRAP, a specific oligopeptide agonist of PAR1. These results identify a no ...[more]
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