Dataset Information

Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial.

ABSTRACT:

Objective

To determine whether vaccination of care home staff against influenza indirectly protects residents.

Design

Pair matched cluster randomised controlled trial.

Setting

Large private chain of UK care homes during the winters of 2003-4 and 2004-5.

Participants

Nursing home staff (n=1703) and residents (n=2604) in 44 care homes (22 intervention homes and 22 matched control homes).

Interventions

Vaccination offered to staff in intervention homes but not in control homes.

Main outcome measures

The primary outcome was all cause mortality of residents. Secondary outcomes were influenza-like illness and health service use in residents.

Results

In 2003-4 vaccine coverage in full time staff was 48.2% (407/884) in intervention homes and 5.9% (51/859) in control homes. In 2004-5 uptake rates were 43.2% (365/844) and 3.5% (28/800). National influenza rates were substantially below average in 2004-5. In the 2003-4 period of influenza activity significant decreases were found in mortality of residents in intervention homes compared with control homes (rate difference -5.0 per 100 residents, 95% confidence interval -7.0 to -2.0) and in influenza-like illness (P=0.004), consultations with general practitioners for influenza-like illness (P=0.008), and admissions to hospital with influenza-like illness (P=0.009). No significant differences were found in 2004-5 or during periods of no influenza activity in 2003-4.

Conclusions

Vaccinating care home staff against influenza can prevent deaths, health service use, and influenza-like illness in residents during periods of moderate influenza activity.

Trial registration

National Research Register N0530147256.

SUBMITTER: Hayward AC

PROVIDER: S-EPMC1702427 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial.

Hayward Andrew C AC Harling Richard R Wetten Sally S Johnson Anne M AM Munro Susan S Smedley Julia J Murad Shahed S Watson John M JM

BMJ (Clinical research ed.) 20061201 7581

<h4>Objective</h4>To determine whether vaccination of care home staff against influenza indirectly protects residents.<h4>Design</h4>Pair matched cluster randomised controlled trial.<h4>Setting</h4>Large private chain of UK care homes during the winters of 2003-4 and 2004-5.<h4>Participants</h4>Nursing home staff (n=1703) and residents (n=2604) in 44 care homes (22 intervention homes and 22 matched control homes).<h4>Interventions</h4>Vaccination offered to staff in intervention homes but not in ...[more]

PMID: 17142257

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Dataset Information

Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial.

Objective

Design

Setting

Participants

Interventions

Main outcome measures

Results

Conclusions

Trial registration

Publications

Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial.

Similar Datasets

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