Ontology highlight
ABSTRACT:
SUBMITTER: Han GW
PROVIDER: S-EPMC170898 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Han Gye Won GW Kopka Mary L ML Langs David D Sawaya Michael R MR Dickerson Richard E RE
Proceedings of the National Academy of Sciences of the United States of America 20030718 16
An intermolecular intercalation of base pairs was found at the CA step in the I222 crystal structure of the RNA.DNA hybrid, r(CAAAGAAAAG).d(CTTTTCTTTG), which contains two-thirds of the polypurine tract sequence of HIV-1 with a substitution of cytosine for the initial adenine. This sequence crystallized in both P212121 and I222 space groups, with an rms difference of only 0.63 A between residues 3 to 18 of the two forms. P212121 and I222 helices are both A-like, but intercalation occurs only in ...[more]