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L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons.

ABSTRACT: Glial cells support the survival and development of central neurons through the supply of trophic factors. Here we demonstrate that l-serine (l-Ser) and glycine (Gly) also are glia-derived trophic factors. These amino acids are released by astroglial cells and promote the survival, dendritogenesis, and electrophysiological development of cultured cerebellar Purkinje neurons. Although l-Ser and Gly are generally classified as nonessential amino acids, 3-phosphoglycerate dehydrogenase (3PGDH), a key enzyme for their biosynthesis, is not expressed in Purkinje neurons. By contrast, the Bergman glia, a native astroglia in the cerebellar cortex, highly expresses 3PGDH. These data suggest that l-Ser and Gly mediate the trophic actions of glial cells on Purkinje neurons.

SUBMITTER: Furuya S

PROVIDER: S-EPMC17234 | biostudies-literature | 2000 Oct

REPOSITORIES: biostudies-literature

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L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons.

Furuya S S Tabata T T Mitoma J J Yamada K K Yamasaki M M Makino A A Yamamoto T T Watanabe M M Kano M M Hirabayashi Y Y

Proceedings of the National Academy of Sciences of the United States of America 20001001 21

Glial cells support the survival and development of central neurons through the supply of trophic factors. Here we demonstrate that l-serine (l-Ser) and glycine (Gly) also are glia-derived trophic factors. These amino acids are released by astroglial cells and promote the survival, dendritogenesis, and electrophysiological development of cultured cerebellar Purkinje neurons. Although l-Ser and Gly are generally classified as nonessential amino acids, 3-phosphoglycerate dehydrogenase (3PGDH), a k ...[more]

PMID: 11016963

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