Ontology highlight
ABSTRACT:
SUBMITTER: Incardona JP
PROVIDER: S-EPMC17291 | biostudies-literature | 2000 Oct
REPOSITORIES: biostudies-literature
Incardona J P JP Lee J H JH Robertson C P CP Enga K K Kapur R P RP Roelink H H
Proceedings of the National Academy of Sciences of the United States of America 20001001 22
Patched (Ptc) is the ligand-binding component of the Hedgehog (Hh) receptor complex. In the Drosophila embryo, Ptc and Hh colocalize in vesicular punctate structures. However, receptor-mediated endocytosis of Hh proteins has not been demonstrated. By using chick neural plate explants, we show that Sonic hedgehog (Shh)-responsive neural precursor cells internalize recombinant and endogenous Shh and provide direct evidence for a gradient of endogenous Shh in the ventral neural tube. Shh internaliz ...[more]