Evolutionary theory for modifiers of epistasis using a general symmetric model.
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ABSTRACT:
SUBMITTER: Liberman U
PROVIDER: S-EPMC1748238 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Publications
Evolutionary theory for modifiers of epistasis using a general symmetric model.
Liberman Uri U Feldman Marcus W MW
Proceedings of the National Academy of Sciences of the United States of America 20061213 51
Genetic interactions in fitness are studied by using modifier theory. The effects on fitness of two linked genes are perturbed by alleles at a third linked locus that controls the extent of epistasis in fitness between the first two. This epistasis is determined by a symmetric interaction matrix, and it is shown that a modifier allele that increases epistasis will invade when the linkage between the other two genes is sufficiently tight and these genes are in linkage disequilibrium. With linkage ...[more]
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