The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor.

ABSTRACT: Voltage-gated calcium channels play a central role in regulating the electrical and biochemical properties of neurons and muscle cells. One of the ways in which calcium channels regulate long-lasting neuronal properties is by activating signaling pathways that control gene expression, but the mechanisms that link calcium channels to the nucleus are not well understood. We report that a C-terminal fragment of Ca(V)1.2, an L-type voltage-gated calcium channel (LTC), translocates to the nucleus and regulates transcription. We show that this calcium channel associated transcription regulator (CCAT) binds to a nuclear protein, associates with an endogenous promoter, and regulates the expression of a wide variety of endogenous genes important for neuronal signaling and excitability. The nuclear

SUBMITTER: Gomez-Ospina N 

PROVIDER: S-EPMC1750862 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature