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Dynamics of Helicobacter pylori colonization in relation to the host response.

ABSTRACT: The dynamics of Helicobacter pylori colonization from its acquisition through the development of steady-state are examined through a mathematical model that includes the host response. The model encompasses both host and microbiological variation. The individual capacity of the host response is shown to be a key model parameter, leading to either transient or persistent colonization, whereas the growth rate of that response has little effect. Analyses of competing strains indicate that each must occupy a specific niche, otherwise exclusion occurs. The model implies that there exists a lower bound on the host response to the indigenous microflora that is consistent with current biological views of H. pylori. Parallel models may be useful in understanding other persistent host-microbial interactions.

SUBMITTER: Blaser MJ

PROVIDER: S-EPMC17522 | biostudies-literature | 1999 Jul

REPOSITORIES: biostudies-literature

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Dynamics of Helicobacter pylori colonization in relation to the host response.

Blaser M J MJ Kirschner D D

Proceedings of the National Academy of Sciences of the United States of America 19990701 15

The dynamics of Helicobacter pylori colonization from its acquisition through the development of steady-state are examined through a mathematical model that includes the host response. The model encompasses both host and microbiological variation. The individual capacity of the host response is shown to be a key model parameter, leading to either transient or persistent colonization, whereas the growth rate of that response has little effect. Analyses of competing strains indicate that each must ...[more]

PMID: 10411880

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