Ontology highlight
ABSTRACT:
SUBMITTER: Berra E
PROVIDER: S-EPMC175782 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Berra Edurne E Benizri Emmanuel E Ginouvès Amandine A Volmat Véronique V Roux Danièle D Pouysségur Jacques J
The EMBO journal 20030801 16
Hypoxia-inducible factor (HIF), a transcriptional complex conserved from Caenorhabditis elegans to vertebrates, plays a pivotal role in cellular adaptation to low oxygen availability. In normoxia, the HIF-alpha subunits are targeted for destruction by prolyl hydroxylation, a specific modification that provides recognition for the E3 ubiquitin ligase complex containing the von Hippel-Lindau tumour suppressor protein (pVHL). Three HIF prolyl-hydroxylases (PHD1, 2 and 3) were identified recently in ...[more]