Ontology highlight
ABSTRACT:
SUBMITTER: Lan ZJ
PROVIDER: S-EPMC175795 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Lan Zi-Jian ZJ Gu Peili P Xu Xueping X Jackson Kathy J KJ DeMayo Francesco J FJ O'Malley Bert W BW Cooney Austin J AJ
The EMBO journal 20030801 16
To determine the function of germ cell nuclear factor (GCNF) in female reproduction, we generated an oocyte-specific GCNF knockout mouse model (GCNF(fl/fl)Zp3Cre(+)). These mice displayed hypofertility due to prolonged diestrus phase of the estrous cycle and aberrant steroidogenesis. These reproductive defects were secondary to a primary defect in the oocytes, in which expression of the paracrine transforming growth factor-beta signaling molecules, bone morphogenetic protein 15 (BMP-15) and grow ...[more]