Ontology highlight
ABSTRACT:
SUBMITTER: Ferguson AD
PROVIDER: S-EPMC1760641 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Ferguson Andrew D AD Amezcua Carlos A CA Halabi Najeeb M NM Chelliah Yogarany Y Rosen Michael K MK Ranganathan Rama R Deisenhofer Johann J
Proceedings of the National Academy of Sciences of the United States of America 20061229 2
Transcription of the ferric citrate import system is regulated by ferric citrate binding to the outer membrane transporter FecA. A signal indicating transporter occupancy is relayed across the outer membrane to energy-transducing and regulatory proteins embedded in the cytoplasmic membrane. Because transcriptional activation is not coupled to ferric citrate import, an allosteric mechanism underlies this complex signaling mechanism. Using evolution-based statistical analysis we have identified a ...[more]