Genomic and transcriptional analysis of protein heterogeneity of the honeybee venom allergen Api m 6.
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ABSTRACT:
SUBMITTER: Peiren N
PROVIDER: S-EPMC1761135 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Publications
Genomic and transcriptional analysis of protein heterogeneity of the honeybee venom allergen Api m 6.
Peiren N N de Graaf D C DC Evans J D JD Jacobs F J FJ
Insect molecular biology 20061001 5
Several components of honeybee venom are known to cause allergenic responses in humans and other vertebrates. One such component, the minor allergen Api m 6, has been known to show amino acid variation but the genetic mechanism for this variation is unknown. Here we show that Api m 6 is derived from a single locus, and that substantial protein-level variation has a simple genome-level cause, without the need to invoke multiple loci or alternatively spliced exons. Api m 6 sits near a misassembled ...[more]
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