FMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease.

ABSTRACT:

Objective

To determine whether APOE genotype influences brain response and whether nonverbal stimuli generate findings comparable with those of previous studies that used verbal stimuli. The relationship between APOE genotype and blood oxygenation level dependent (BOLD) brain response was examined during a picture-encoding task in nondemented older adults.

Methods

Twenty nondemented participants with normal episodic memory function were divided into two groups based on the presence (n = 10) or absence (n = 10) of the APOE epsilon4 allele. Picture learning was completed during functional MRI in a blocked design alternating between experimental (novel pictures) and control (repeated picture) conditions.

Results

Nondemented older adults with an APOE epsilon4 allele showe

SUBMITTER: Bondi MW 

PROVIDER: S-EPMC1761695 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature