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Building epidemiological models from R0: an implicit treatment of transmission in networks.

ABSTRACT: Simple deterministic models are still at the core of theoretical epidemiology despite the increasing evidence for the importance of contact networks underlying transmission at the individual level. These mean-field or 'compartmental' models based on homogeneous mixing have made, and continue to make, important contributions to the epidemiology and the ecology of infectious diseases but fail to reproduce many of the features observed for disease spread in contact networks. In this work, we show that it is possible to incorporate the important effects of network structure on disease spread with a mean-field model derived from individual level considerations. We propose that the fundamental number known as the basic reproductive number of the disease, R0, which is typically derived as a threshold quantity, be used instead as a central parameter to construct the model from. We show that reliable estimates of individual level parameters can replace a detailed knowledge of network structure, which in general may be difficult to obtain. We illustrate the proposed model with small world networks and the classical example of susceptible-infected-recovered (SIR) epidemics.

SUBMITTER: Aparicio JP

PROVIDER: S-EPMC1766386 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature

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Building epidemiological models from R0: an implicit treatment of transmission in networks.

Aparicio Juan Pablo JP Pascual Mercedes M

Proceedings. Biological sciences 20070201 1609

Simple deterministic models are still at the core of theoretical epidemiology despite the increasing evidence for the importance of contact networks underlying transmission at the individual level. These mean-field or 'compartmental' models based on homogeneous mixing have made, and continue to make, important contributions to the epidemiology and the ecology of infectious diseases but fail to reproduce many of the features observed for disease spread in contact networks. In this work, we show t ...[more]

PMID: 17476770

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Building epidemiological models from R0: an implicit treatment of transmission in networks.

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Building epidemiological models from R0: an implicit treatment of transmission in networks.

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