Unknown

Dataset Information

0

Detection of human papillomavirus in large cell neuroendocrine carcinoma of the uterine cervix: a study of 12 cases.

ABSTRACT: AIM:To investigate the role of human papillomavirus (HPV) in large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix. METHODS:Twelve archival, immunohistochemically and/or electron microscopically confirmed cases of cervical LCNEC were studied. Non-isotopic in situ hybridisation (NISH) was performed on the formalin fixed, paraffin wax embedded biopsies using digoxigenin labelled probes to HPV types 6, 11, 16, 18, 31, and 33. The tumours were then subjected to polymerase chain reaction (PCR) analysis using GP5+/GP6+ consensus primers to the HPV L1 gene, in addition to type specific primers to the E6 and E6/E7 genes. RESULTS:HPV-16 was detected by NISH and/or PCR in seven of the 12 carcinomas. Two additional tumours were HPV-18 positive by NISH and/or PCR. HPV DNA was not detected in the three remaining cases. CONCLUSION:Integration of high risk HPV, in particular type 16 and to a lesser extent type 18, is associated with this uncommon variant of cervical carcinoma.

SUBMITTER: Grayson W 

PROVIDER: S-EPMC1769596 | biostudies-literature | 2002 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Detection of human papillomavirus in large cell neuroendocrine carcinoma of the uterine cervix: a study of 12 cases.

Grayson W W   Rhemtula H A HA   Taylor L F LF   Allard U U   Tiltman A J AJ  

Journal of clinical pathology 20020201 2

<h4>Aim</h4>To investigate the role of human papillomavirus (HPV) in large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix.<h4>Methods</h4>Twelve archival, immunohistochemically and/or electron microscopically confirmed cases of cervical LCNEC were studied. Non-isotopic in situ hybridisation (NISH) was performed on the formalin fixed, paraffin wax embedded biopsies using digoxigenin labelled probes to HPV types 6, 11, 16, 18, 31, and 33. The tumours were then subjected to polymerase  ...[more]

Similar Datasets

Unknown Clinicopathological Analysis of Neuroendocrine Carcinoma of the Uterine Cervix: A Single-Institution Retrospective Review of 9 Cases.
| S-EPMC8463196 | biostudies-literature
Unknown Microarray comparative genomic hybridization detection of chromosomal imbalances in uterine cervix carcinoma.
| S-EPMC1186020 | biostudies-literature
Unknown Next-generation Sequencing Reveals Recurrent Somatic Mutations in Small Cell Neuroendocrine Carcinoma of the Uterine Cervix.
| S-EPMC5943084 | biostudies-literature
Unknown Dysregulation of Transcription Factor Networks Unveils Different Pathways in Human Papillomavirus 16-Positive Squamous Cell Carcinoma and Adenocarcinoma of the Uterine Cervix.
| S-EPMC8170088 | biostudies-literature
Unknown Urinary Large Cell Neuroendocrine Carcinoma: A Clinicopathologic Analysis of 22 Cases.
| S-EPMC8428850 | biostudies-literature
Unknown Co-expression of SOX2 and HR-HPV RISH predicts poor prognosis in small cell neuroendocrine carcinoma of the uterine cervix.
| S-EPMC8011148 | biostudies-literature
Unknown Histology-specific FGFR2 alterations and FGFR2-TACC2 fusion in mixed adenoid cystic and neuroendocrine small cell carcinoma of the uterine cervix.
| S-EPMC7672274 | biostudies-literature
Unknown Natural history and outcome of neuroendocrine carcinoma of the cervix.
| S-EPMC4844781 | biostudies-literature
Unknown Comparative genomics of high grade neuroendocrine carcinoma of the cervix.
| S-EPMC7297329 | biostudies-literature
Unknown Prognostic factors and outcomes of early-stage small cell neuroendocrine carcinoma of the cervix: 37 cases from a single center.
| S-EPMC6501769 | biostudies-literature