Ontology highlight
ABSTRACT:
SUBMITTER: Ramalho JS
PROVIDER: S-EPMC1772060 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Ramalho J S JS Gregory-Evans K K Huxley C C Seabra M C MC
The British journal of ophthalmology 20040301 3
<h4>Background/aims</h4>To report the generation of a new mouse model for a genetically determined corneal abnormality that occurred in transgenesis experiments.<h4>Methods</h4>Transgenic mice expressing mutant forms of Rab27a, a GTPase that has been implicated in the pathogenesis of choroideremia, were generated.<h4>Results</h4>Only one transgenic line (T27aT15) exhibited an unexpected eye phenotype. T27aT15 mice developed corneal opacities, usually unilateral, and cataracts, resulting in some ...[more]